Phosphatidic Acid | It's Uses, Benefits & Side Effects


Phosphatidic acid was a very popular muscle building supplement amongst bodybuilders in the 1970s & 80s, and now with recent scientific research and noticeable physiological results, Phosphatidic acid is returning to its former glory. This article provides a complete user's guide to Phosphatidic acid, including what it is, what it does and how to take it.

What is Phosphatidic Acid

Phosphatidic acid (sometimes referred to as PA) is a type of lipid, which can also be classified as an MTOR agonist. Any supplement that positively affects or upregulates the MTOR pathway can be defined as being anabolic (muscle-building). Greater activation of the MTOR pathway leads to augmented muscle protein synthesis, which is the process required for muscle repair and growth.

Ultimately, taking Phosphatidic acid whilst following a resistance training regime will amplify your gains beyond that would occur without taking the supplement.

Phosphatidic Acid Benefits

Improves Lean Muscle Mass

A study conducted in the U.S.A (2016) found PA alongside other synergistic mTOR signaling substances to significantly improve lean muscle mass and strength, when compared to a control group that followed the same 8 week training regime and diet plan (1).

One of the largest studies done on Phosphatidic acid also found that males taking a 750mg dose alongside resistance training resulted in an increase in 1 rep Max (1RM) and an increase in lean body mass. (2)

Increases Strength Alongside Training

The same study published in JISSN reported that daily 500mg PA supplementation, alongside 4 day per week resistance training for 8 weeks significantly improves strength and muscle mass gains when compared to a placebo group. This study also reported a significant increase in 1RM scores in the PA group compared to the control group, as well as a decrease in fat mass (3).

Helps With Gastrointestinal Disorders

During one study, phosphatidic acid has shown to help optimise hormonal levels to prevent or restore gastrointestinal disorders, such as diarrhoea and stomach ulcers (4).

It Is Not a Banned Substance

One of the big advantages phosphatidic acid has is it is completely safe and natural to use. If you are a drug-tested athlete or your work requires a drug test you can rest easy that phosphatidic acid does not cause any side effects or flag up for any banned or illegal compounds. 

Phosphatidic Acid Side Effects

Supplements that provoke muscle growth to the extent of Phosphatidic acid are usually accompanied by steroidal side effects, however PA is completely natural and safe, and is suitable for drug tested athletes and does not show up on any drug tests. 

Additionally, alongside Phosphatidic acid's ability to boost muscle protein synthesis and improve lean body mass, it also has various beneficial side effects. Anecdotal research suggests that PA helps to optimise hormonal levels and strengthen your immune system, which is essential for any active individual or athlete.

Phosphatidic acid Dosage & Cycle

Keeping in line with the academic research and customer feedback, we advise running Phosphatidic acid for 8-12 weeks at 500mg per day. However, as this supplement is not androgenic and non-suppressive, and doesn't cause any negative side effects, it could be run indefinitely. 

Although, we do advise an 8-12 week cycle, with no post-cycle therapy (PCT) required. It is strongly advised to take Phosphatidic acid with food, as it is a lipid molecule itself. 

Where to buy Phosphatidic Acid Supplements

At Prohormones UK, we offer Phosphatidic Acid supplements by German Pharma, Epistan!  Epistan contains 500mg per serving (2 capsules). 


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