L-Arginine + Citrulline

L-Arginine and L-Citrulline are two amino acids that are highly popular in sports nutrition for their role in enhancing nitric oxide production in the body.

Nitric oxide is a potent vasodilator, meaning it relaxes the inner muscles of your blood vessels, causing them to widen. This vasodilation effect is key for athletes and those looking to improve cardiovascular health, as it promotes increased blood flow to the muscles.

When consumed together, L-Arginine + Citrulline create a highly efficient system for sustained nitric oxide production. While L-Arginine is a direct precursor to nitric oxide, much of it is broken down before it can be fully utilised.

Citrulline, however, serves as a powerful precursor to L-Arginine, effectively bypassing the initial breakdown process and significantly raising plasma levels of L-Arginine in the bloodstream.

This recycling pathway means that the combination provides both an immediate boost from the L-Arginine and a longer-lasting, more potent surge of nitric oxide derived from the converted Citrulline, maximising the benefits for circulation, muscle fullness, and overall workout quality.

L-Arginine + Citrulline is generally considered safe for short-term use, but they can cause side effects, particularly related to the digestive system.

The most commonly reported adverse effects for L-Arginine include nausea, abdominal pain, diarrhoea, and bloating. These gastrointestinal issues can occur because high doses of L-Arginine may induce water and electrolyte secretion in the intestine.

Citrulline is typically better tolerated and is less likely to cause digestive upset, though some users report stomach discomfort or heartburn.

More importantly, because both amino acids are powerful precursors to nitric oxide and promote vasodilation, they may interact with certain medications and existing health conditions by lowering blood pressure.