Dienedione (Tren)

key facts

Legal Status (US): Listed as a controlled substance

Average Dose:
100-200mg/day standalone
50-100mg/day when stacking

Average Cycle Length: 4-6 weeks

Dienedione is a non-methylated steroid that converts to a steroid known as 17b-hydroxy-estra-4,9,(10)-dien-3-one (dienolone).

Although dienedione may have some anabolic activity on its own, it gets most of its effects from conversion to dienedrone by interaction with 17b-HSD. This steroids overall effects are somewhere between trenbolone and nandrolone.

Dienedione is known for causing night sweats via its powerful thermogenic effects similar to trenbolone. This thermogenic effect makes dienedione an excellent choice for dropping bodyfat during cutting cycles.

As a 19-nor this compound has decent progestational effects which may lead to gyno symptoms, libido loss and aggressive mood swings. Part of the reason gyno may be a problem with this compound is also because it lacks androgenic potency and down-regulates DHT levels during cycle, which is the body’s natural estrogen blocker.

Dienedione does not convert to estrogen, although it can still lead to the side-effects mentioned above. Because this compound is not 17aa liver toxicity is not really a concern. However some users have reported elevated liver enzyme values during cycle, although this could be related to other factors.

Users usually experience rapid gains in strength and aggression, followed by significant weight gain after several weeks. The results are generally fairly lean with only minor bloat due to the progestational effects.

Dienedione can be used as a standalone. In an effort to prevent libido loss and gyno, it may be stacked with testosterone or one of its non-aromatizing metabolites to help keep DHT levels elevated during cycle.

Common Clones:
Dienedrone by Advanced Muscle Science (AMS)
Liquidrone UTT by Advanced Muscle Science (AMS)
X-Tren by Competitive Edge Labs (CEL)
Tren Xtreme by American Cellular Labs
Tren 250 by Genetic Edge Technologies (GET)
Trena by Nutracoastal

the science

Chemical Name(s):
4,9 Estra

Chemical Formula: C18H22O2
Molecular Weight: 270
Q Qatio: NA
Anabolic #: NA
Androgenic #: NA
Oral Bioavailability: Estimated at 20%
AR Binding Affinity: 5
SHBG Binding Affinity: NA
Half Life: NA

related product


Anabolic Pharmacology
Seth Roberts (2009)